In collaboration with the Tanzania National Institute for Medical Research (NIMR) and London School of Hygiene and Tropical Medicine (LSHTM)

Site preparation and capacity strengthening for trials of vaginal microbicides in Tanzania and Uganda (Women's Health Project)

Principal Investigators: Richard Hayes, Saidi Kapiga

Project Coordinators: Tony Ao, Joseph Chilongani

Funding: European and Developing Countries Clinical Trials Partnership (EDCTP)

End of the project dissemination meeting.

Summary: There is an urgent need for effective vaginal microbicides that women can use to protect themselves against heterosexually-acquired HIV infection. Current clinical trial capacity in sub-Saharan Africa is insufficient to test new microbicides coming through the development pipeline. This three-year project aims at strengthening research capacity for trials of vaginal microbicides in Tanzania and Uganda. The main objectives are:

Counseling room

  • To strengthen research capacity of MITU and MRC/UVRI Uganda Research Unit on AIDS to carry out future microbicide trials to international ICH/GCP standards. This will include strengthening of laboratory and clinical facilities to support phase I, II and III clinical trials, improvement of the ethical review process, work to ensure access of trial participants to appropriate HIV care, and development and training of local scientists in the skills required to carry out clinical trials and contribute in developing future research leaders.
  • To establish new study cohorts in towns and roadside settlements near Mwanza, Tanzania (in the towns of Geita, Shinyanga, and Kahama) and in Kampala, Uganda. In each site, women at high risk of HIV infection will be recruited in a feasibility study and followed up for 12 months to determine retention rates, and estimate the prevalence and incidence of HIV, other sexually transmitted infections and pregnancy. In addition, to develop and test study procedures, and establish an effective community liaison system.